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Therapeutics
Adding aripiprazole improves major depressive disorder following incomplete response to antidepressants alone

http://dx.doi.org/10.1136/ebmh.11.1.15

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    Robert M Berman, MD

    Bristol-Myers Squibb Co., 5 Research Parkway, Wallingford, CT 06492, USA; Robert.Berman@bms.com

    QUESTION

    Question:

    How effective and safe is aripiprazole when added to antidepressants in people with major depressive disorder and a history of incomplete response?

    Patients:

    362 adults with major depressive disorder (DSM-IV-TR) whose current episode had failed to show complete response to an 8-week trial of standard antidepressant plus adjunctive placebo. Incomplete response was defined as <50% reduction in 17-item Hamilton Rating Scale for Depression (HAM-D17) total score, HAM-D17 score ⩾14, and a Clinical Global Impressions-Improvement scale score ⩾3. Participants enrolled in the 8-week trial had to have HAM-D17 total score ⩾18, and a history of inadequate response (<50% reduction in Massachusetts General Hospital Antidepressant Treatment Response Questionnaire (ATRQ)) to 1–3 adequate antidepressant treatments (>6 weeks using adequate dose as specified in the ATRQ) for their current depressive episode.

    Setting:

    24 sites in the USA; June 2004 to April 2006.

    Intervention:

    Adjunctive aripiprazole (2–20 mg daily depending on antidepressant being …

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    Footnotes

    • Source of funding: Bristol-Myers Squibb Co and Otsuka Pharmaceutical Co, Ltd.

    Footnotes

    • Competing interests: None declared.