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Review: Adding second generation antipsychotics to mood stabilisers reduces acute mania symptoms

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What is the effect of second generation antipsychotics, alone or in combination with mood stabilisers, in people with acute mania?

Scherk H, Pajonk FG, Leucht S. Second-generation antipsychotic agents in the treatment of acute mania: a systematic review and meta-analysis of randomized controlled trials. Arch Gen Psychiatry 2007;64:442–55.


Embedded ImageDesign:

Systematic review with meta-analysis.

Embedded ImageData sources:

PsiTri database and MEDLINE (search date May 2006), plus hand searches of references, contact with experts in the field.

Embedded ImageStudy selection and analysis:

The review included randomised controlled trials (RCTs) of second generation antipsychotics (aripiprazole, amisulpride, clozapine, olanzapine, quetiapine, risperidone, ziprasidone, zotepine) for treatment of acute mania. Continuous data were presented as standardised mean differences with confidence intervals, which were calculated based on Hedges adjusted g (modified Cohen’s d corrected for samples sizes below 10). If standard deviations were not reported, values were derived from p values or mean standard deviation of other studies. …

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  • Sources of funding: None reported.


  • Competing interests: None declared.