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Bridge JA, Iyengar S, Salary CB, et al. Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment - a meta-analysis of randomized controlled trials. JAMA 2007;297:1683–96.
Systematic review with meta-analysis.
PubMed (January 1988 to July 2006); abstracts of scientific meetings; FDA and MHRA reports; reference lists of articles; clinical trial registries; and contact with authors.
Study selection and analysis:
Randomised controlled trials (RCTs) comparing second generation antidepressants versus placebo, in children and adolescents (aged <19 years) with major depressive disorder (MDD), OCD or non-OCD anxiety disorders. Data on suicide outcomes were obtained from an FDA review of antidepressants and paediatric suicidal behaviour, study reports and from investigators. Exclusions were: studies of tricyclic antidepressants or monoamine oxidase inhibitors; crossover RCTs; studies in treatment responders only; studies still recruiting patients; use of cognitive behavioural therapy; inability to obtain data from author; or studies of anxiety-related …
Sources of funding: Not stated; study authors were funded by the National Institute of Mental Health, National Institutes of Health, and Robert Wood Johnson Foundation.
Competing interests: None.