Statistics from Altmetric.com
Q Do antidepressants increase the risk of self-harm or suicidal behaviour in children and adolescents?
Systematic review with meta-analysis.
UK Committee for Safety of Medicines (CSM) review up to January 2004; Medline and PsycINFO from January 2004 to August 2005; the Cochrane Database; the GlaxoSmithKline website for paroxetine, and contact with researchers in the field.
Study selection and analysis:
Randomised controlled trials (RCTs) in children and adolescents with a major depressive disorder comparing antidepressants versus placebo for 8–12 weeks.
Suicide-related events (attempted suicide, suicidal thoughts or self-harm from CSM data; or worsening suicide ideation or suicide attempt or both from Treatment for Adolescents with Depression Study).
Sixteen RCTs met inclusion criteria (n = 2741; …
For correspondence: Dr Bernadka Dubicka, University Department of Child and Adolescent Psychiatry, Royal Manchester Children’s Hospital, Pendlebury, Manchester M27 4HA, UK;
Sources of funding: Not stated.
Competing interests: None declared.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.