Article Text

Quetiapine more effective than placebo for depression in bipolar I and II disorder

Statistics from

OpenUrlCrossRefPubMedWeb of Science

Q How effective is quetiapine monotherapy for depression in people with bipolar I or II disorder?


Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Double blind.

Embedded ImageFollow-up period:

Eight weeks.

Embedded ImageSetting:

Forty one centres in the US; June 2004 to August 2005.

Embedded ImagePatients:

509 outpatients (18–65 years old) with DSM-IV bipolar I (n = 338) or II (n = 171) disorder experiencing a major depressive episode (17-item Hamilton Depression Rating Scale (HAM-D17) score ⩾20, HAM-D17 Item 1 score ⩾2; Young Mania Rating Scale score ⩽12). Participants were excluded if they had: been diagnosed with another Axis I disorder that had been treated within 6 months before the study; a current depressive episode lasting more than 12 months or less than 4 …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.