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Q Are citalopram or interpersonal psychotherapy more effective than placebo or clinical management for major depression in people with coronary artery disease?
METHODS
Design:
Randomised controlled 2×2 factorial trial.
Allocation:
Concealed.
Blinding:
Double blind for citalopram and placebo; single blind for interpersonal psychotherapy (IPT) or clinical management (assessors blind).
Follow-up period:
Twelve weeks (treatment period only).
Setting:
Nine academic centres, Canada; May 2002 to March 2006.
Patients:
284 outpatients (⩾18 years old) with DSM-IV major depression for ⩾4 weeks, Hamilton Depression rating scale (HAM-D) score ⩾20, and established coronary artery disease (previous myocardial infarction or revascularisation; or angiographic evidence of ⩾50% stenosis in ⩾1 major coronary artery). Main exclusions: depression with psychotic features; bipolar disorder; substance abuse; serious suicidal risk; taking antidepressants, anticonvulsants, lithium, or undergoing psychotherapy; previous non-response to citalopram or IPT; ⩾2 …
Footnotes
For correspondence: François Lespérance, MD, Centre Hospitalier de l’Université de Montréal, 1560 Sherbrooke E, Montreal, Quebec, Canada H2L 4M1; francois.lesperance{at}umontreal.ca
Competing interests: None.
Sources of funding: Canadian Institutes of Health Research (CIHR) Clinical Trials Programme, Fondation du Centre Hospitalier de l’Université de Montréal, and the Fondation de l’Institut de Cardiologie de Montréal.
Footnotes
For reference list please see http://ebmh.bmj.com/supplemental
Competing interests: None declared.
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