Article Text
Statistics from Altmetric.com
OpenUrlCrossRefPubMedWeb of Science
Q Are citalopram or interpersonal psychotherapy more effective than placebo or clinical management for major depression in people with coronary artery disease?
METHODS
Design:
Randomised controlled 2×2 factorial trial.
Allocation:
Concealed.
Blinding:
Double blind for citalopram and placebo; single blind for interpersonal psychotherapy (IPT) or clinical management (assessors blind).
Follow-up period:
Twelve weeks (treatment period only).
Setting:
Nine academic centres, Canada; May 2002 to March 2006.
Patients:
284 outpatients (⩾18 years old) with DSM-IV major depression for ⩾4 weeks, Hamilton Depression rating scale (HAM-D) score ⩾20, and established coronary artery disease (previous myocardial infarction or revascularisation; or angiographic evidence of ⩾50% stenosis in ⩾1 major coronary artery). Main exclusions: depression with psychotic features; bipolar disorder; substance abuse; serious suicidal risk; taking antidepressants, anticonvulsants, lithium, or undergoing psychotherapy; previous non-response to citalopram or IPT; ⩾2 …
Request Permissions
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.