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Q How effective are electroconvulsive therapy or lithium carbonate plus nortriptyline hydrochloride as maintenance treatments in major depression?
METHOD
Design:
Randomised controlled trial.
Allocation:
Unconcealed.
Blinding:
Unblinded.
Follow-up period:
Six months (treatment period only).
Setting:
Five academic medical centres (outpatient psychiatry clinics) in the US; 1997–2004.
Patients:
Phase 1 (acute non-randomised treatment): 531 people aged 18–85 years with primary DSM-IV major depression (24-item Hamilton Rating Scale for Depression (HRSD) total score ⩾21) referred for bilateral electroconvulsive therapy (ECT). Phase 2 (maintenance treatment): 201 people with remission in phase 1 (⩾60% decrease from baseline in HRSD total score and HRSD score ⩽10 on two consecutive ratings), an HRSD score ⩽10 or less for 1 week without psychotropic medication, and modified Mini-Mental State Examination (mMMSE) …
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