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Q How do second generation antipsychotics compare with haloperidol for the treatment of acute schizophrenia?
Randomised controlled trial.
Unblinded (treating physician and participant aware of the treatment). Assessors of the Brief Psychiatric Rating Scale and side effects were blinded; the unblinded treating physician made the decision about discharge.
At least 3 weeks.
Six hospital adult psychiatric inpatient units, USA; recruitment January 2004 to February 2005.
327 newly admitted adult inpatients (aged 18 years and over) with DSM-IV schizophrenia, schizoaffective disorder or schizophreniform disorder. Exclusions: substance-induced psychotic disorder, bipolar disorder, major depressive disorder, history of non-response to study drugs or response to non-study drugs, pregnancy or breastfeeding, or medical condition contraindicating study treatments.
Aripiprazole, haloperidol, …
For correspondence: Dr Robert E McCue, Department of Psychiatry, Woodhull Medical and Mental Health Center, 760 Broadway, Brooklyn, New York, USA;
Sources of funding: Not stated.
Competing interests: Professor Taylor has received research funding and consultancy fees from all manufacturers of currently marketed second generation antipsychotics.
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