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Adherence therapy does not improve quality of life in people with schizophrenia

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Q Does adherence therapy improve quality of life in people with schizophrenia?


Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Single blind (assessors blinded).

Embedded ImageFollow-up period:

One year (including 8-week treatment period).

Embedded ImageSetting:

Inpatient and community psychiatric services in four European cities (Amsterdam, London, Leipzig and Verona); recruitment June 2002 to October 2003.

Embedded ImagePatients:

409 adults with ICD-10 schizophrenia and evidence of clinical instability in the preceding year (change in medication, increased contact with mental health services, psychiatric hospital admission, or reported clinical instability) needing antipsychotic medication. Exclusion criteria: alcohol or drug dependence; organic brain disorder or mental handicap; receiving forensic psychiatric services.

Embedded ImageIntervention:

Adherence therapy (see 8 weekly sessions of individual cognitive-behavioural therapy, or …

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  • For correspondence: Dr Richard Gray, Health Services Department, Institute of Psychiatry, King’s College London, De Crespigny Park, London SE5 8AF, UK; R.Gray{at}

  • Source of funding: The Quality of Life and Management of Living Resources Programme of the European Union.


  • Competing interests: None declared.