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  • Bipolar I disorder is common in first-degree relatives of children with prepubertal and early adolescent bipolar I disorder

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Prevalence
Bipolar I disorder is common in first-degree relatives of children with prepubertal and early adolescent bipolar I disorder

http://dx.doi.org/10.1136/ebmh.10.2.63

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    Geller B, Tillman R, Bolhofner K, et al. Controlled, blindly rated, direct-interview family study of a prepubertal and early-adolescent bipolar I disorder phenotype: morbid risk, age at onset, and comorbidity. Arch Gen Psychiatry 2006;63:1130–8.OpenUrlCrossRefPubMedWeb of Science

    Q How common is bipolar I disorder in relatives of children with prepubertal and early adolescent bipolar disorder?

    METHODS

    Embedded ImageDesign:

    Cross-sectional study.

    Embedded ImageSetting:

    St Louis, USA; interviews conducted September 1999 to April 2004.

    Embedded ImagePopulation:

    690 first-degree relatives (age ⩾6 years) of 219 children (probands) with prepubertal and early adolescent bipolar I disorder (PEA-BP-I; 95 children with DSM-IV criteria for mania with ⩾1 cardinal mania symptom; 284 relatives), DSM-IV attention deficit/hyperactivity disorder (ADHD; 47 children, 143 relatives) or healthy matched controls (77 children matched to PEA-BP-I group for age, gender, ethnicity, socioeconomic status and area of residence; 263 relatives). No exclusion criteria were given for first degree relatives. Exclusions for probands: poor physical health; bipolar I disorder <2 weeks (PEA-BP-I probands only); lifetime or …

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    Footnotes

    • For correspondence: Barbara Geller, MD, Department of Psychiatry, Washington University in St Louis, 660 South Euclid Avenue, St Louis, MO 63110-1093, USA; gellerb{at}medicine.wustl.edu

    • Source of funding: National Institute of Mental Health, USA.