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Q Is clozapine more effective than other second-generation antipsychotics for people with resistant schizophrenia?
METHODS
Design:
Randomised controlled trial.
Allocation:
Concealed.
Blinding:
Single blind (assessors blinded).
Follow-up period:
Twelve months.
Setting:
Five centres, UK; time period not stated.
Patients:
136 adults (18–65 years old) with DSM-IV schizophrenia, schizoaffective or delusional disorder and poor clinical response to at least two other treatments. Exclusions: neuroleptic malignant disorder, substance misuse or medical disorder responsible for psychotic symptoms.
Intervention:
Clozapine (end dose range 100–600 mg/day; mean end dose 333 mg/day) or other second-generation antipsychotic (amisulpride 600–800 mg/day (mean 683 mg/day), olanzapine 10–30 mg/day …
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