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Quetiapine is no less effective than risperidone for reducing symptoms of schizophrenia

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Q Is quetiapine as effective and tolerable as risperidone for adults with schizophrenia?


Embedded ImageDesign:

Randomised controlled non-inferiority trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Double blind.

Embedded ImageFollow-up period:

Eight weeks (treatment period only).

Embedded ImageSetting:

66 centres, USA; enrolment June 2001 to September 2002.

Embedded ImagePatients:

673 adults (aged 18–65 years) with DSM-IV schizophrenia. Inclusion criteria: Positive and Negative Syndrome Scale (PANSS) total score ⩾60; score ⩾4 on delusions, conceptual disorganisation, hallucinations, suspiciousness, or persecution PANSS items; Clinical Global Impression Scale Severity of Illness score ⩾4; and evidence of deterioration in the 3 weeks prior to randomisation. Exclusions: other DSM-IV axis I disorder; intolerance or previous non-response to study drugs; use of clozapine in last month; psychotic …

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  • For correspondence: D E Sweitzer, AstraZeneca Pharmaceuticals LP, 1800 Concord Pike, Wilmington, DE 19850, USA; dennis.sweitzer{at}

  • Source of funding: AstraZeneca.