Article Text

Download PDFPDF
Review: pharmacotherapy and psychotherapy similarly effective for depression in older adults

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

OpenUrlCrossRefPubMedWeb of Science

Q Is pharmacotherapy more effective than psychotherapy for depressed older adults?


Embedded ImageDesign:

Systematic review with meta analysis.

Embedded ImageData sources:

MEDLINE, Cochrane Database, PsycINFO, and PSYNDEX (search date not stated).

Embedded ImageStudy selection and analysis:

Included studies compared pharmacotherapeutic or psychotherapeutic interventions versus control (eg, placebo or waiting list) in older adults (mean or median age ⩾60 years) with major or minor depressive or dysthymic disorder (ICD-10, DSM-III, DSM-IIIR or DSM-IV). Exclusions: combined, maintenance or collaborative treatments; studies recording insufficient data for analysis. Continuous measures were meta-analysed with Cohen’s d using a random-effects model. Odds ratios and Mantel–Haenszel effect estimates were calculated for dichotomous outcomes.

Embedded ImageOutcomes:

Clinician-rated or self-rated symptom severity, response, remission.


Eighty nine controlled studies, including 70 randomised controlled trials …

View Full Text


  • For correspondence: Dr Pinquart, Institute of Psychology, University of Jena, Am Steiger 3, Haus 1, 07743 Jena, Germany; martin.pinquart{at}

  • Source of funding: National Institute of Mental Health, USA.