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Benefits of bright light in non-seasonal major depression not sustained after discontinuation

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Q Is the effect of bright light when given in combination with an antidepressant for non-seasonal major depression sustained following discontinuation of light therapy?


Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Double blind.

Embedded ImageFollow-up period:

Nine weeks (5 weeks’ treatment plus 4 weeks‘ follow-up).

Embedded ImageSetting:

Participants referred from general practices in the greater Copenhagen area, Denmark, July 2001 to June 2003.

Embedded ImagePatients:

102 adults aged 18–76 years old with DSM-IV major depression. Main exclusions: DSM-IV seasonal affective disorder, psychotic disorder, organic brain disorder, alcohol or drug abuse; retinal blindness or cataract; history of light induced migraine or epilepsy; pregnancy or ineffective contraceptive method; mental retardation; significant suicidal ideation; severe agitation; or 17-item Hamilton Depression Rating Scale (HAMD17) score <13.

Embedded ImageIntervention:

Fixed dose sertraline (50 mg daily) plus either bright light …

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  • For correspondence: Dr Klaus Martiny, Psychiatric Research Unit, Frederiksborg General hospital, Dyrehavevej 48, DK-3400 Hillerød, Denmark

  • Sources of funding: The Danish Medical Research Council; Eastern Region Research Foundation; Merchant L F Foght’s Foundation; Johannes M Klein and Wife’s Memorial Foundation; The Tvergaard Foundation; The Danish Psychiatric Association; Olga Bryde Nielsen’s Foundation; The AP Møller and Chastine McKinney Møller Foundation; The Region 3 Foundation; The Frederiksborg General Hospital Research Fund.