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Escitalopram 10 mg daily is more effective than paroxetine and placebo for generalised anxiety disorder

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Q Is escitalopram more effective than paroxetine or placebo for people with generalised anxiety disorder?


Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Double blind.

Embedded ImageFollow-up period:

Twelve weeks (treatment period).

Embedded ImageSetting:

Sixty three centres in 10 countries; time period not stated.

Embedded ImagePatients:

681 people with generalised anxiety disorder (DSM-IV-TR; aged 18–65 years; 64% female), Hamilton Anxiety Scale (HAMA) total score ⩾20, and HAMA anxious mood and tension items scores ⩾2. Exclusions: DSM-IV-TR major depressive, panic, social anxiety, post-traumatic stress, bipolar, obsessive-compulsive, eating, body dysmorphic, substance misuse or personality disorders in the last 6 months; current or previous DSM-IV-TR psychotic disorder; suicidal; cognitive-behavioural, electroconvulsive, cognitive or problem solving therapy; other serious medical condition; …

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  • For correspondence: David S Baldwin, University Department of Mental Health, Royal South Hants Hospital, Graham Road, Southampton SO14 0YG, UK; dsbl{at}

  • Source of funding: Lundbeck A/S, Denmark.