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Therapeutics
Escitalopram 10 mg daily is more effective than paroxetine and placebo for generalised anxiety disorder

http://dx.doi.org/10.1136/ebmh.10.2.45

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    Baldwin DS, Huusom AKT, Maehlum E. Escitalopram and paroxetine in the treatment of generalised anxiety disorder—randomised, placebo-controlled, double-blind study. Br J Psychiatry 2006;189:264–72.OpenUrlAbstract/FREE Full Text

    Q Is escitalopram more effective than paroxetine or placebo for people with generalised anxiety disorder?

    METHODS

    Embedded ImageDesign:

    Randomised controlled trial.

    Embedded ImageAllocation:

    Concealed.

    Embedded ImageBlinding:

    Double blind.

    Embedded ImageFollow-up period:

    Twelve weeks (treatment period).

    Embedded ImageSetting:

    Sixty three centres in 10 countries; time period not stated.

    Embedded ImagePatients:

    681 people with generalised anxiety disorder (DSM-IV-TR; aged 18–65 years; 64% female), Hamilton Anxiety Scale (HAMA) total score ⩾20, and HAMA anxious mood and tension items scores ⩾2. Exclusions: DSM-IV-TR major depressive, panic, social anxiety, post-traumatic stress, bipolar, obsessive-compulsive, eating, body dysmorphic, substance misuse or personality disorders in the last 6 months; current or previous DSM-IV-TR psychotic disorder; suicidal; cognitive-behavioural, electroconvulsive, cognitive or problem solving therapy; other serious medical condition; …

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    Footnotes

    • For correspondence: David S Baldwin, University Department of Mental Health, Royal South Hants Hospital, Graham Road, Southampton SO14 0YG, UK; dsbl{at}soton.ac.uk

    • Source of funding: Lundbeck A/S, Denmark.