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The articles we select for Evidence-Based Mental Health must pass two stages: first they must pass our basic validity criteria and then the editors assess each article for clinical relevance. A number of articles meet the inclusion criteria but are not abstracted due to lack of space. We will highlight the most interesting of these here and list the rest.
Alogia, avolition, affective flattening, and associality: for many people with schizophrenia, negative symptoms are the most disabling component of the illness. They are difficult to define, hard to measure, and seemingly intractable. Atypical antipsychotics have been marketed as an effective treatment based on brief trials in acutely unwell patients. Hence a year-long study of patients with predominantly negative symptoms should be welcomed ( OpenUrlCrossRefPubMedWeb of Science) . Both olanzapine and risperidone were helpful but olanzapine had the edge (no prizes for guessing the study sponsor). Disappointingly for a “real-world” study the benefits were more obvious at a statistical level than a clinical one, so it looks like the jury is still out on this question. Atypical antipsychotics are getting everywhere and this small randomized trial tries out aripiprazole in borderline personality disorder (BPD) ( OpenUrlCrossRefPubMedWeb of Science) . In the absence of …
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