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Randomised controlled trial.
Single blind (assessors blinded).
Follow up period:
Twelve weeks (treatment period only).
Outpatient setting in Brazil; March 2002 to December 2003.
Fifty six adults (mean 38.5 years) with diagnosed with DSM-IV obsessive-compulsive disorder (OCD; Mini-International Neuropsychiatric Interview – Brazilian version), and a Yale-Brown Obsessive Compulsive Scale (YBOCS) score of ⩾16. Main exclusion criteria: moderate to severe major depression, Beck Depression Inventory score >16, bipolar disorder, severe personality disorder, psychotic disorder, substance related disorder in the previous six months, Tourette’s syndrome, or organic brain disease.
Group cognitive behavioural therapy (CBT; weekly two-hour group session) or sertraline (50 mg/day in the …
For correspondence: Aristides V Codioli, MD, PhD, Department of Psychiatry, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, Room 400N, Porto Alegre, RS, Brazil 90035-903;
Sources of funding: Coordenacao de Aperfeicoamento de Ensino Superior (CAPES), Fundacao de Incentivo a Pesquisa e a Eventos (FIPE) at the Hospital de Clinicas de Porto Alegre, Brazil. Sertraline was provided by Pfizer Inc, Sao Paulo, Brazil.