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Review: antipsychotic augmentation is effective for people with obsessive-convulsive disorder who are receiving, but not responding to, serotonin reuptake inhibitor monotherapy

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Q Does augmentation with antipsychotics improve outcome for people with refractory obsessive-compulsive disorder who are not responding to serotonin reuptake inhibitor monotherapy?

METHODS

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Systematic review with meta-analysis.

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PubMed and PsychINFO (1967–2005), EMBASE (1974–2000) and the Cochrane Central Register of Controlled Trials (Issue 3, 2005). Reference lists were hand searched.

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Eligible studies were double blinded, randomised controlled trials (RCTs) that compared augmentation with antipsychotic versus placebo in adults with obsessive-compulsive disorder that had not responded to ⩾2 months serotonin reuptake inhibitor (SRI) monotherapy, and that used the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) as an outcome measure. Pooled absolute risk difference (RD) was used to analyse proportion of treatment responders and number needed to treat …

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Footnotes

  • For correspondence: Dr M H Bloch, Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06520, USA; michael.bloch{at}yale.edu

  • Sources of funding: not stated.

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