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Risperidone improves symptoms in people who are hospitalised during an acute exacerbation of schizophrenia

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Q What are the relative efficacies of the atypical antipsychotics, risperidone and quetiapine, and placebo for people with schizophrenia who have been hospitalised following a recent exacerbation of their illness?


Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Double blinded.

Embedded ImageFollow up period:

Two weeks.

Embedded ImageSetting:

Thirty centres in the USA, India and Romania; time frame not reported.

Embedded ImagePatients:

382 adults (18–64 years) requiring hospitalisation for a recent exacerbation (within the last 4 weeks) of DSM-IV schizophrenia or schizoaffective disorder (confirmed by MINI-Plus), with Clinical Global Impressions of Severity (CGI-S) ⩾5, and with a score of ⩾4 on at least two of the following on total Positive and Negative Syndrome Scale (PANSS): hostility; excitement; …

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  • For correspondence: Steven G Potkin, University of California, Irvine, Department of Psychiatry and Human Behaviour, Brain Imaging Centre, Irvine Hall, Room 166, Irvine, CA 92696-3960, USA; sgpotkin{at}

  • Source of funding: Janssen, LP.