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Q How effective is aripiprazole for preventing relapse in people with bipolar I disorder who have recently been stabilised with aripiprazole after experiencing a manic or mixed episode?
Randomised controlled trial.
Follow up period:
Twenty six weeks (treatment period).
Seventy six centres, Mexico, US and Argentina; enrolment: March 2000 to June 2003.
161 adults with a manic or mixed episode of DSM-IV bipolar I disorder whose symptoms stabilised after 6–18 weeks open-label 15 or 30 mg/day aripiprazole (lower dose used if higher dose not tolerated; stabilisation defined as total Young Mania Rating Scale score ⩽10 and Montgomery-Asberg Depression Rating Scale score ⩽13 in four consecutive visits over 6 weeks). Exclusions: cognitive disorder, schizophrenia, or schizoaffective disorder; psychotic symptoms explained by substance …
For correspondence: Paul E Keck Jr, MD, Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Martin Luther King Drive, Cincinnati, OH 45267, USA;
Sources of funding: Bristol-Myers Squibb Co, USA and Otsuka Pharmaceutical Co, Japan.
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