Article Text

Download PDFPDF
Combined olanzapine plus fluoxetine modestly improves symptoms of acute bipolar I depression compared to lamotrigine

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


Q What is the efficacy and safety of combined olanzapine plus fluoxetine compared with lamotrigine in bipolar I depression?


Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

Seven weeks (treatment period only).

Embedded ImageSetting:

Thirty eight sites in the US; November 2003 to August 2004.

Embedded ImagePatients:

410 adult outpatients or hospital inpatients with bipolar I depression (Structured Clinical Interview for DSM-IV); a total score of ⩾20 on the Montgomery-Asberg depression rating scale (MADRS); a score of ⩾4 (moderately ill) on the Clinical Global Impressions-Severity of Illness scale (CGI-S); and at least one previous manic or mixed episode that was severe enough to warrant treatment with a mood stabiliser or antipsychotic. Exclusions: current DSM-IV …

View Full Text


  • For correspondence: Eileen B Brown, PhD, Eli Lilly and Co, Lilly Corporate Center, Drop Code 4133, Indianapolis, IN 46285, USA; ebrown{at}

  • Source of funding: Eli Lilly and Co, Indianapolis.