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Review: atypical antipsychotics are effective for treating bipolar mania

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Q Are atypical antipsychotics effective as monotherapies or as adjunctive therapy for bipolar mania?


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Systematic review and meta-analysis.

Embedded ImageData sources:

MEDLINE and PubMed (search date 2004); abstracts from the 2003 meetings of the American College of Neuropsychiatry, American Psychiatric Association, and International Conference on Bipolar Disorder; and contact with investigators and drug manufacturers.

Embedded ImageStudy selection and analysis:

Placebo controlled, randomised controlled trials (RCTs) of atypical antipsychotics (aripiprazole, clozapine, quetiapine, risperidone, ziprasidone, olanzapine) as monotherapy or adjunctive therapy (in addition to lithium, valproate, or carbamazepine) for acute bipolar mania. Meta-analysis was conducted using a random-effects model.

Embedded ImageOutcomes:

Manic symptoms (change in Young Mania Rating Scale (YMRS) or Mania Rating Scale (MRS) from baseline to endpoint using last observation carried forward …

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  • For correspondence: Roy H Perlis, MD, Massachusetts General Hospital, Harvard Bipolar Research Program, 15 Parkman Street, WACC 812, Boston, MA 02114, USA; rperlis{at}

  • Source of funding: National Institute of Mental Health, Bethesda, Maryland, USA.

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