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In the absence of a true diagnostic standard, 2 methods were used to determine accuracy: (1) blinded comparison between the clinician's diagnosis and the consensus best estimate; and (2) accuracy of 3 raters estimated using latent class analysis.
Southern Ontario, Canada.
143 children (mean age 113 months, 76% boys) with various types of developmental disabilities and with a possible diagnosis of PDD made by a referring health professional. Children with any neurological or chromosomal condition that had known genetic implications were excluded.
Description of tests and diagnostic standard
Patients were diagnosed as PDD, PDD subtype, or non-PDD by 1 experienced physician using a clinical assessment, available clinical records, the Autism Diagnostic Interview-Revised (ADI-R) and the Autism Diagnostic …
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