Article Text

Download PDFPDF

Review: apolipoprotein E ε4 allele is a risk factor for Alzheimer's disease in different ethnic groups

Statistics from

OpenUrlCrossRefPubMedWeb of Science

Question What is the effect of age, sex, and ethnicity on the association between apolipoprotein E (APOE) genotype and Alzheimer's disease (AD)?

Data sources

A Medline search was done to assist in identifying research groups known to be investigating the association between APOE ε4 allele and AD. The research groups were invited to provide data sets on their patients.

Study selection

The data sets included patients who had definite or probable AD (5930 patients). Patients with mutations in the amyloid precursor protein gene and the presenilin genes or coexisting neuropathological problems were excluded. Control group participants had no neurodegenerative or neuropsychiatric illnesses (8607 patients).

Data extraction

The data sets from the centres were reviewed for sampling strategies (cohort, case control, and cross sectional designs); recruitment settings (community, clinic or hospital, and …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles