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Review: apolipoprotein E ε4 allele is a risk factor for Alzheimer's disease in different ethnic groups
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Question What is the effect of age, sex, and ethnicity on the association between apolipoprotein E (APOE) genotype and Alzheimer's disease (AD)?

Data sources

A Medline search was done to assist in identifying research groups known to be investigating the association between APOE ε4 allele and AD. The research groups were invited to provide data sets on their patients.

Study selection

The data sets included patients who had definite or probable AD (5930 patients). Patients with mutations in the amyloid precursor protein gene and the presenilin genes or coexisting neuropathological problems were excluded. Control group participants had no neurodegenerative or neuropsychiatric illnesses (8607 patients).

Data extraction

The data sets from the centres were reviewed for sampling strategies (cohort, case control, and cross sectional designs); recruitment settings (community, clinic or hospital, and …

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