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Long term amphetamine treatment improved behaviour in children with attention deficit hyperactivity disorder

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Question In children with attention deficit hyperactivity disorder (ADHD), can long term stimulant treatment improve behaviour?


Randomised, double blind, placebo controlled trial with 18 months follow up.


4 university departments of child and adolescent psychiatry in Sweden.


72 children 6–11 years of age who met ≥8 of the 14 DSM-III-R criteria for ADHD. Exclusion criteria were IQ <50, chronic medical conditions, receiving ongoing medication (except for epilepsy), height 2 standard deviations below the norm, major psychosocial problems, or a history of alcohol or drug abuse in the patient or the principal caretaker. 62 patients (mean age 9 y, 82% boys, 42% with comorbid diagnosis) were randomised. 10 patients were withdrawn before randomisation.


Initially, all patients participated in …

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