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Haloperidol plus amitriptyline was superior to risperidone in a psychotic and depressive syndrome

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Question In patients with combined psychotic and depressive syndrome, is risperidone effective compared with haloperidol plus amitriptyline for improving psychotic and depressive symptoms?


6 week randomised, double blind, controlled trial.


Clinical centres in Austria and Germany*.


123 patients (62% women) who were 19 to 63 years of age; had comorbid major depression with paranoid or hallucinatory symptoms, or both; scored ≥60 points on the Positive and Negative Syndrome Scale (PANSS) with ≥4 points scored on the positive symptoms subscale; and scored ≥15 points on the Bech-Rafaelsen Melancholia Scale (BRMES) with ≥3 points scored on its depression item. Diagnoses according to DSM-III-R were major depression with psychotic features (31%); …

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