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Cognitive behavioural therapy improved overall symptomatology in patients with medication resistant psychosis

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Question In patients with medication resistant psychosis, can cognitive behavioural therapy (CBT) improve overall symptomatology?


Randomised controlled trial with 9 months follow up.


3 sites in the UK: Maudsley Trust, Addenbrooke's Hospital Trust, and Norfolk Mental Health Trust.


60 patients (mean age 40 y, 63% men, mean duration of illness 13 y) with ≥1 positive psychotic symptom (eg, delusions or hallucinations) which was distressing, unremitting, and medication resistant (ie, not responsive to ≥6 months of an appropriate neuroleptic medication). Patients who had drug, alcohol, or organic problems as primary features were excluded.


28 patients were allocated to CBT plus standard treatment and 32 patients were allocated to standard treatment …

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