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Review: heterocyclic antidepressants and rational psychological therapies are effective in older patients with mild to moderate depression

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Question In older ambulatory patients with depression, how effective are acute phase pharmacological and psychological treatments?

Data sources

Studies were identified by searching Medline (1981 to March 1995) using the subject headings depressive disorder, depression, aged, and clinical trials; and by searching PsycINFO (1984 to March 1995) using the subject headings major depression, aged, and therapy or treatment. Additional studies were identified by reviewing the bibliographies of articles and books.

Study selection

English or French language original studies were selected if they evaluated the effectiveness of acute phase pharmacological or psychological treatment using a prospective controlled study design in patients ≥55 years of age with depression in an outpatient, community, or nursing home setting.

Data extraction

Data were extracted on sample size, mean depression rating scale scores at the beginning and end of treatment for each …

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