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Review: clozapine reduces relapse and symptoms compared with typical neuroleptic drugs in schizophrenia

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Objective

To compare the effectiveness of clozapine with typical neuroleptic drugs in patients with schizophrenia.

Data sources

Studies were identified by searching Biological Abstracts (January 1982 to May 1995), Cochrane Schizophrenia Groups' Register, EMBASE (January 1980 to May 1995), Medline (January 1966 to May 1995), PsycLIT (January 1974 to May 1995), and SCISEARCH, as well as by scanning the reference list of retrieved articles and by contacting authors of recent trials and the manufacturer of clozapine.

Study selection

Studies were selected if they were randomised controlled trials that compared the effectiveness of clozapine with typical neuroleptic drugs in patients with schizophrenia. Principal outcomes of …

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