Donepezil v placebo in mild or moderate Alzheimer's disease†

Outcomes at 12 to 24 weeksDonepezil doseWeighted comparisonRRR (95% CI)NNT (CI)
Unchanged or
worsened global 10 mg/day70% v 86%19% (10 to 27)7 (5 to 10)
clinical states5 mg71% v 86%17% (10 to 24)7 (5 to 13)
RRI (CI)NNH (CI)
†Abbreviations defined in glossary; RRR, RRI, NNT, NNH, and CI calculated from data in article.
Withdrawals10 mg/day23% v 14%62% (15 to 129)12 (7 to 30)