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Clinical imaging in dementia with Lewy bodies
  1. Ajenthan Surendranathan,
  2. John Tiernan O’Brien
  1. Department of Psychiatry, University of Cambridge, Cambridge, UK
  1. Correspondence to Dr Ajenthan Surendranathan, Department of Psychiatry, University of Cambridge, CCB2 0QQ, UK; as2489{at}medschl.cam.ac.uk

Abstract

Dementia with Lewy bodies (DLB) is a common neurodegenerative dementia in older people; however, the clinical features, particularly cognitive fluctuations and rapid eye movement sleep disorder, are often hard to elicit, leading to difficulty in making the diagnosis clinically. Here we examine the literature for the evidence behind imaging modalities that could assist in making the diagnosis. Dopamine transporter (DAT) imaging remains the best modality for differentiation from dementia of Alzheimer’s type with high sensitivity and specificity reported based on pathological diagnoses. 123Iodine-metaiodobenzylguanidine myocardial scintigraphy (MIBG) however is rapidly becoming an alternative imaging modality for the diagnosis of DLB, though studies assessing its accuracy with postmortem verification are still awaited. However, there are suggestions that MIBG may be better in the differentiation of vascular parkinsonism from DLB than DAT scans but may have lower sensitivity for detecting DLB compared with the 80% sensitivity seen in DAT imaging. Structural MRI scans have long been used for the diagnosis of dementia; however, their utility in DLB is limited to revealing the presence of coexisting Alzheimer’s disease. Fluorodeoxyglucose (FDG) PET is an alternative biomarker that can also differentiate Alzheimer’s disease and DLB but lacks the evidence base of both DAT and MIBG scans.

  • dementia
  • neuroradiology

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Footnotes

  • Funding National Institute for Health Research (NIHR) Cambridge Dementia Biomedical Research Centre based at the Cambridge Biomedical Campus has supported the writing of the paper but did not have a role in the decision to submit for publication or the design of the review.

  • Competing interests None declared.

  • Patient consent Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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