Article Text

PDF
Commentary
Increased serotonin 1A receptor availability in the raphe nuclei predicts future suicidal behaviour
  1. Andreas Frick1,2
  1. 1Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
  2. 2Department of Psychology, Uppsala University, Uppsala, Sweden
  1. Department of Psychology, Uppsala University, Box 1225, 751 42 Uppsala, Sweden; Andreas.Frick{at}psyk.uu.se

Statistics from Altmetric.com

ABSTRACT FROM: Oquendo MA, Galfalvy H, Sullivan GM, et al. Positron emission tomographic imaging of the serotonergic system and prediction of risk and lethality of future suicidal behavior. JAMA Psychiatry 2016;73:1048–55.

What is already known on this topic

Each year, suicide ends an estimated 800 000 lives worldwide.1 Thus, identifying risk factors of future suicidal behaviour is of great importance. Accumulating evidence for the last 40 years have linked suicide to alterations in the central serotonergic system,2 but prospective studies predicting future suicidal behaviour from brain serotonin measures are lacking.

Methods of the study

Brain serotonin 1A (n=100) and serotonin transporter (n=50) binding potentials were investigated in vivo in patients with major depressive disorder using positron emission tomography (PET) with the radiotracers [11C]WAY100635 and [11C]DASB, respectively. The patients scored >15 on the Hamilton Depression Rating Scale (17-item), indicating at least moderate …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.