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ABSTRACT FROM: Buntrock C, Ebert DD, Lehr D, et al. Effect of a web-based guided self-help intervention for prevention of major depression in adults with subthreshold depression: a randomized clinical trial. JAMA 2016;315:1854–63.
What is already known on this topic
The available treatments can only moderately reduce the enormous burden of disease associated with depression.1 Prevention of the transition from subthreshold depression to a full-blown disorder is therefore highly needed. Offering accessible and affordable preventive interventions at a large scale, such as web-based interventions, could be an indispensable strategy to reduce the global burden of depression.
Methods of the study
In the study by Buntrock and colleagues, 406 adults with subthreshold depression (Centre for Epidemiological Studies-Depression Scale score ≥16, but no current major depressive disorder (MDD) according to the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, SCID) were randomly assigned between March 2013 and March 2015 to a web-based self-help intervention (n=202) …
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