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Improving outcome of bipolar disorder when considering glucose metabolism
  1. Francesco Benedetti,
  2. Sara Dallaspezia
  1. Department of Clinical Neuroscience, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
  1. Correspondence to Dr Francesco Benedetti; benedetti.francesco{at}hsr.it

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ABSTRACT FROM: Calkin CV, Ruzickova M, Uher R, et al. Insulin resistance and outcome in bipolar disorder. Br J Psychiatry 2015;206:52–7.

What is already known on this topic?

Patients with bipolar disorder have a three times increased risk of type 2 diabetes (T2D) compared with the general population.1 This is of clinical significance, because bipolar disorder complicated by T2D is associated with greater morbidity, and greater chronicity and disability.2 However, little is known about the impact of insulin resistance on course of illness.

Methods of the study

A cross-sectional study considered 121 participants affected by bipolar disorder type I or II, from the Mood Disorders Program at Dalhousie University and from the Maritime Bipolar Registry in the Atlantic Provinces of Canada. No exclusion criteria are indicated in the study.

Clinical course and treatment history were assessed with the National Institute of Mental Health Life Chart method, using month ratings listed by the affecting person. (The ratings specify the polarity and the severity of episodes and their course, also recording the concomitant use/impact of medication and life events that may precipitate episodes.) …

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