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ABSTRACT FROM: Graff-Guerrero A, Rajji TK, Mulsant BH, et al. Evaluation of antipsychotic dose reduction in late-life schizophrenia: a prospective dopamine D2/3 receptor occupancy study. JAMA Psychiatry 2015;72:927–34.
What is already known on this topic
The use of lower doses of antipsychotics is recommended by experts in the treatment of older patients with schizophrenia, with the literature suggesting that older age is related to greater antipsychotic sensitivity.1 To date, three randomised controlled trials have examined the effects of olanzapine and risperidone dose reduction on clinical outcome in schizophrenia with inconsistent results.2–4 However, this topic has not been addressed specifically in older patients with schizophrenia, nor has the relationship between decreased dopamine D2/3 receptor occupancy and clinical response.
Methods of the study
The study, using [11C]-raclopride positron emission tomography (PET), is an open-label, single-arm, prospective study. A total of 35 outpatients, 50 years or older, with clinically stable schizophrenia and receiving the …
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