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Current antipsychotic drug treatment may increase the risk of pulmonary embolism
  1. Marie Tournier
  1. Université de Bordeaux, INSERM, Centre Hospitalier Charles Perrens, Bordeaux, France; mtournier@ch-perrens.fr

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ABSTRACT FROM: Conti V, Venegoni M, Cocci A, et al. Antipsychotic drug exposure and risk of pulmonary embolism: a population-based, nested case-control study. BMC Psychiatry 2015;15:92.

What is already known on this topic

A recent meta-analysis only identified three studies that investigated the association between pulmonary embolism and exposure to antipsychotics.1 It failed to detect a significant association, but the effect size was high and the CI was very wide, raising some concerns about a possible lack of statistical power (OR 4.90, 95% CI 0.77 to 30.98). This nested case–control study was conducted to assess whether exposure to antipsychotics is associated with an increased risk of pulmonary embolism, using a large administrative claims database.

Methods of the study

Data were extracted from the regional health insurance database of Lombardy, Italy. The database routinely collects demographic and administrative information, as well as data on drugs dispensed outside hospitals and on hospital discharge forms with diagnoses.

 The study included 84 253 patients aged 18 years and over who were starting a new antipsychotic drug treatment, over 2 years, from 1 January 2012 to 31 December 2013. Patients with a recorded diagnosis of neoplasm, hip …

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