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Improving the treatment for depressive symptoms and major depression with anti-inflammatory drugs
  1. Patricia A Zunszain
  1. Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; patricia.zunszain@kcl.ac.uk

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ABSTRACT FROM: Köhler O, Benros ME, Nordentoft M, et al. Effect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects: a systematic review and meta-analysis of randomized clinical trials. JAMA Psychiatry 2014;71:1381–91.

What is already known on this topic

Major depression and depressive symptoms may be associated with an inflammatory state: subgroups of depressed patients show elevated levels of cytokines,1 ,2 autoimmune diseases and infections are known risk factors for mood disorders3 and treatment with proinflammatory agents induces symptoms of depression.4 This study investigated the promising effects of anti-inflammatory drugs used in addition or instead of traditional antidepressants, which have shown to improve symptoms but where possible adverse side effects are a concern.

Methods of the study

This systematic review evaluated 14 randomised placebo-controlled trials assessing the efficacy and adverse effects of pharmacological anti-inflammatory treatment in 6262 adults with major depression or depressive symptoms. The study included papers published prior to 31 December 2013 and were …

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