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Understanding the course of cognitive deficits over the onset of psychosis
  1. Ashleigh Lin1,
  2. Stephen J Wood2,3
  1. 1Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia
  2. 2School of Psychology, University of Birmingham, Birmingham, UK
  3. 3Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne & Melbourne Health, Melbourne, Australia
  1. Correspondence to Professor Stephen J Wood; s.j.wood{at}bham.ac.uk

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ABSTRACT FROM: Bora E, Murray RM. Meta-analysis of cognitive deficits in ultra-high risk to psychosis and first episode psychosis: do the cognitive deficits progress over, or after, the onset of psychosis? Schizophrenia Bulletin 2014;40:744–55.

What is already known on this topic?

People with a first-episode of psychosis (FEP) show cognitive impairments relative to healthy controls that are present at the onset of psychotic disorder.1 Individuals at ultra-high risk (UHR) for psychosis tend to show cognitive performance intermediate to FEP and healthy controls, suggesting there may be deterioration in cognitive ability over the transition to psychotic disorder. The only way to truly determine deterioration in cognition is through longitudinal within-subject studies. A relatively large number of studies of FEP suggest no deterioration is evident in the first few years postpsychosis onset.2 Longitudinal UHR studies show similar results, but these often have small sample sizes.3 ,4

Methods of the study

Bora and Murray performed a meta-analysis …

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