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Elevated C reactive protein in adults predicts the later development of late-onset or very-late-onset schizophrenia
  1. Faith Dickerson
  1. Correspondence to Sheppard Pratt Health System, 6501 North Charles St, Baltimore, MD 21204, USA; fdickerson{at}sheppardpratt.org

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ABSTRACT FROM: Wium-Andersen MK, Ørsted DD, Nordestgaard BG. Elevated C-reactive protein associated with late- and very-late-onset schizophrenia in the general population: a prospective study. Schizophr Bull 2014;40:1117–27.

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Some cross-sectional studies have shown that individuals with schizophrenia have higher levels of some markers of inflammation, including pro-inflammatory cytokines and C reactive protein (CRP), than controls.1 ,2 CRP is one of the most commonly used markers of inflammation. During acute inflammation (eg, bacterial infection), levels of CRP may increase up to 300-fold.3 In apparently healthy individuals, plasma levels of CRP are usually below 3 mg/L but can be up to 10 mg/L;4 however, slightly elevated CRP levels below 10 mg/L in normal subjects may indicate a state of low-grade inflammation3 which has been associated with increased risk of several diseases, including major depression and bipolar disorder.5 It has also been shown that a history of autoimmune disease or severe infection increases the …

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