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Antidepressant exposure during the first trimester does not increase the risk of cardiac malformations in infants
  1. Jennifer L Payne
  1. Correspondence to Dr Jennifer L Payne, Department of Psychiatry, Johns Hopkins School of Medicine, 550 N. Broadway, Suite 305, Baltimore, MD 21205, USA; Jpayne5{at}

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ABSTRACT FROM: Huybrechts KF, Palmsten K, Avorn J, et al. Antidepressant use in pregnancy and the risk of cardiac defects. N Engl J Med 2014;370:2397–407.

What is already known on this topic?

Previous studies have had conflicting and inconsistent findings regarding the rates of cardiac malformations in infants exposed to antidepressant medications during the first trimester. Concerns remain, particularly with regard to paroxetine, which has been associated with ventricular outflow tract obstruction,1 and sertraline, which has been associated with ventral septal defects.1 ,2 It has remained unclear if these associations are causal or if risk factors having to do with the underlying illness, depression, play a role. The goal of this study was to conduct a large cohort study examining the …

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