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What is already known on this topic?
Postictal psychosis is a well-recognised epileptic phenomenon, while there is also mounting evidence of increased prevalence of interictal psychosis and schizophrenia in people with epilepsy.1 The co-occurrence of these two disease states raises important questions about potentially shared pathological mechanisms and creates important challenges in their medical management.2
What does this paper add?
First systematic review and meta-analysis examining the prevalence of psychosis in people with epilepsy.
Pooled prevalence (a combination of lifetime, period and possibly point prevalence) of psychosis in those with epilepsy (including postictal psychosis, interictal psychosis and schizophrenia; 18 studies are included whose definition of psychosis is presumably unknown) alongside the odds of psychosis relative to those without epilepsy were reported.
The study authors comment on ‘substantial’ heterogeneity between included primary studies (I2>70%), and proceed with the meta-analysis using a random effects model to help accommodate this heterogeneity. Importantly, however, …