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Is ‘clinical high risk (CHR)’ of developing psychosis associated with transition to psychosis?
Risk of transition to psychosis in high-risk patients, and transition risks at 6, 12, 18, 24, 36 and >36 months.
Systematic review and meta-analysis.
PubMed and EMBASE were searched up to January 2011. The authors hand searched reference lists of included articles. Search terms included: psychosis risk, ultra high risk, UHR, prodromal psychosis, psychosis transition, basic symptoms and psychosis onset. No language or date of publication restrictions were applied.
Study selection and analysis
Studies that reported transition risks in patients at high risk for psychosis were included. Inclusion criteria: original papers published in a peer-review journal; involved patients at high risk of psychosis defined by international criteria; reported transition risk to psychosis. Exclusion criteria: criteria for identifying high-risk patients not clearly defined inclusion of patients at genetic risk for schizotypal personality disorder or psychosis; overlapping study samples from the same centre. Demographic, clinical and methodological variables were included as moderators in the meta-regression analysis. Heterogeneity among …
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