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Is sertraline (SRT), cognitive behavioural therapy (CBT) or a combination of the two, effective at inducing remission among children and adolescents with anxiety disorders compared with placebo?
488 children and adolescents aged between 7 and 17 years who met DSM-IV criteria for generalised anxiety disorder, social phobia and/or separation anxiety disorder.
Six sites, USA; from 2003 to 2008.
SRT only, CBT only, SRT and CBT (COMB) or placebo pill treatment for 12 weeks.
Remission, defined in three different ways: (A) loss of all targeted anxiety disorders, assessed using the Anxiety Disorders Interview Schedule; (B) Clinical Global Impression Severity Scale (CGI-S) score of 1 (no symptoms) or 2 (minimal symptoms); (C) Clinical Global Impression Improvement Scale (CGI-I) score of 1 (very much improved).
90% completed the study; 100% included in the analysis.
Randomised controlled trial (the Child/Adolescent Anxiety Multimodal Study, CAMS).
The SRT and PBO arms were double blinded while the CBT and COMB arms were single blinded (assessors only).
Using the loss of anxiety disorder diagnoses as the …
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