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Is ω-3 fatty acid supplementation effective in treating attention deficit hyperactivity disorder (ADHD) symptoms in children?
Primary outcome: change in ADHD severity (standardised mean difference in change between intervention and placebo). Secondary outcome: relationship between dose of different ω-3 fatty acids in supplements and effectiveness.
Systematic review and meta-analysis.
PUBMED was searched from 1965 up to December 2010. Unpublished or ongoing trials were searched for using the ClinicalTrials.gov website. Hand searches of the reference lists of relevant meta-analyses or reviews were also conducted.
Study selection and analysis
Randomised placebo-controlled trials which examined the efficacy of ω-3 fatty acid supplementation in children with ADHD or targeting ADHD symptoms in undiagnosed children or those with comorbidities were included. Studies were required to have used a validated rating scale to measure ADHD symptom severity. Trials where other psychoactive substances were started at the same time as ω-3 fatty acid supplementation were excluded but supplementation was allowed to augment existing pharmacotherapy. RevMan 5 was used to carry out fixed effects meta-analysis of the results, with SPSS 19.0 to carry out meta-regression.
Ten randomised controlled trials (RCTs) in 699 …
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