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Mortality gap between people with schizophrenia or bipolar disorder and the general population persists in England

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Question

Question

Has the risk of mortality in people with schizophrenia or bipolar disorder remained elevated compared with the general population in recent years?

Population

All people with schizophrenia (n=272 248) and bipolar disorder (n=100 851) discharged after hospital inpatient care from 1999 to 2006.

Setting

Inpatient hospital episode statistics in England and death registration data from the Office of National Statistics; from 1999 to 2007.

Prognostic factors

Schizophrenia (international classification of diseases (ICD-10) or bipolar disorder (ICD-10) as the principal diagnosis on the hospital discharge record.

Outcomes

Mortality within 1 year of discharge from psychiatric inpatient care. Causes of death were determined from death certificates (ICD-10). Deaths were classified as unnatural (suicide or deaths from undetermined intent) or natural. Natural deaths were broadly classified as being from respiratory diseases, cardiovascular diseases, cancer or accidents. Age and sex standardised mortality ratios (SMRs) were calculated, comparing mortality in people with schizophrenia or bipolar disorder with mortality in the general population. Standardisation used the indirect method, with the sex and age-specific mortalities …

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