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Q Does the combination of psychotherapy plus antidepressant therapy improve short and long term response rates compared with either therapy alone in people with panic disorder?
Systematic review with meta-analysis.
Cochrane Collaboration Depression, Anxiety and Neurosis Controlled Trials Register, Cochrane Central Register of Controlled Trials, Medline, hand search of reference lists, and contact with experts in the field.
Study selection and analysis:
Inclusions: randomised controlled trials (RCTs) in adults with panic disorder, with or without agoraphobia, which compared any form of psychotherapy or antidepressant therapy alone versus a combination of both treatments. Exclusions: RCTs of antidepressants plus benzodiazepines (although irregular use of benzodiazepines or continued use of benzodiazepines at a stable dose in long term users was permitted). Results were divided by treatment phase: acute treatment (first 2–4 months), continuation treatment (3–9 months), and post-treatment (6–24 months after treatment completion). Review Manager 4.2 software was used to perform random effects meta-analysis. If studies did not carry out last observation carried forward intention to treat analysis, …
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