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Q Are depressive symptoms and vascular disease associated with the risk of developing mild cognitive impairment in elderly people?
Population based longitudinal cohort study.
Follow up period:
Four US communities in North Carolina, Maryland, California, and Pennsylvania; enrolment 1989–90 and 1992–93.
2220 community dwelling adults aged over 65 years. Exclusions: dementia (increasing or stable deficit in at least two cognitive domains, which affected activities of daily living (ADLs), in people with previously normal function) at baseline or final follow up; mild cognitive impairment (Modified Mini-Mental State Examination (3MS) score <90) at 1992–93 testing; receiving any major medical treatment or care, or wheelchair bound.
Depressive symptoms (Center for Epidemiological Studies Depression Scale; maximum score = 30; no depressive symptoms = 0–2; low depressive symptoms = 3–7, moderate or high depressive symptoms ⩾8); any history of vascular disease (confirmed prior stroke or transient ischaemic attack), any …
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