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Schizophrenia: risperidone and olanzapine increase time to discontinuation compared with quetiapine and ziprasidone

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Q What are the effects of risperidone, olanzapine, quetiapine, and ziprasidone on time to discontinuation in people who have discontinued another atypical antipsychotic?

METHODS

Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:

Concealed.

Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

Eighteen months.

Embedded ImageSetting:

Fifty seven clinical sites, USA; from January 2001 to December 2004.

Embedded ImagePatients:

333 people aged between 16 and 65 years with schizophrenia (DSM-IV; mean age 40.8 years; 69% male) who discontinued treatment with the assigned atypical antipsychotic in the first phase of the study (for any reason). Exclusions: prior resistance to study drugs or treatment with clozapine for resistance; history of serious adverse reaction to study drugs; first episode schizophrenia; schizoaffective disorder; mental retardation; cognitive disorder; pregnant; breast feeding; or serious medical comorbidity.

Embedded ImageIntervention:

Olanzapine (7.5–30 mg/day); quetiapine (200–800 mg/day); risperidone (1.5–6 mg/day); …

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