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Q Does long term risperidone maintenance improve symptoms in children and adolescents with disruptive behaviour disorders?
Randomised controlled trial.
Follow up period:
Twenty five centres in six European countries, Israel, and South Africa; 2001–03.
335 children and adolescents (aged 5–17 years) with conduct disorder, oppositional defiant disorder, or disruptive behaviour disorder not otherwise specified (DSM-IV and Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime Version criteria) who responded to 12 weeks of risperidone (0.25 to 1.5 mg/day). Exclusions: moderate or severe intellectual impairment (IQ <55); Nisonger Child Behavior Rating Form - parent version (NCBRF) conduct problem subscale score <24; schizophrenia; bipolar disorder; other serious psychological or medical conditions; use of antispychotics, lithium, anticonvulsants, or antidepressants; or with no responsible caregiver.
Participants were randomised to continuing risperidone treatment (0.25 to 1.5 mg/day) or placebo for six months.
Time to symptom recurrence (defined as a worsening of …
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