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Q Does donepezil improve symptoms in people with severe Alzheimer’s disease?
Randomised controlled trial.
Follow up period:
Fifty nursing homes run by trained staff, Sweden; October 2002 to October 2004.
248 nursing home residents aged over 50 years with possible or probable Alzheimer’s disease (DSM-IV and National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer’s Disease and Related Disorders Association criteria, and consistent CT or MRI scan) that was classed as severe (Mini-Mental State Examination score of 1–10), and with functional assessment staging rating of between 5 and 7c. Exclusions: inability to walk alone or with help; non-Alzheimer’s dementia; or primary psychiatric or neurological disorder.
Donepezil (5 mg/day for first 30 days, increased to 10mg/day for the next 5 months if tolerated) or placebo.
Cognitive function (Severe Impairment Battery (SIB): score …
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