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Donepezil improves cognitive function and reduces decline in activities of daily living in people with severe Alzheimer’s disease

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 Q Does donepezil improve symptoms in people with severe Alzheimer’s disease?

METHODS

Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:

Concealed.

Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

Six months.

Embedded ImageSetting:

Fifty nursing homes run by trained staff, Sweden; October 2002 to October 2004.

Embedded ImagePatients:

248 nursing home residents aged over 50 years with possible or probable Alzheimer’s disease (DSM-IV and National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer’s Disease and Related Disorders Association criteria, and consistent CT or MRI scan) that was classed as severe (Mini-Mental State Examination score of 1–10), and with functional assessment staging rating of between 5 and 7c. Exclusions: inability to walk alone or with help; non-Alzheimer’s dementia; or primary psychiatric or neurological disorder.

Embedded ImageIntervention:

Donepezil (5 mg/day for first 30 days, increased to 10mg/day for the next 5 months if tolerated) or placebo.

Embedded ImageOutcomes:

Cognitive function (Severe Impairment Battery (SIB): score …

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